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Principles Of Research Methodology


Author : Phyllis G. Supino
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-22


PDF Download Principles Of Research Methodology Books For free written by Phyllis G. Supino and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-22 with Medical categories.


Principles of Research Methodology: A Guide for Clinical Investigators is the definitive, comprehensive guide to understanding and performing clinical research. Designed for medical students, physicians, basic scientists involved in translational research, and other health professionals, this indispensable reference also addresses the unique challenges and demands of clinical research and offers clear guidance in becoming a more successful member of a medical research team and critical reader of the medical research literature. The book covers the entire research process, beginning with the conception of the research problem to publication of findings. Principles of Research Methodology: A Guide for Clinical Investigators comprehensively and concisely presents concepts in a manner that is relevant and engaging to read. The text combines theory and practical application to familiarize the reader with the logic of research design and hypothesis construction, the importance of research planning, the ethical basis of human subjects research, the basics of writing a clinical research protocol and scientific paper, the logic and techniques of data generation and management, and the fundamentals and implications of various sampling techniques and alternative statistical methodologies. Organized in thirteen easy to read chapters, the text emphasizes the importance of clearly-defined research questions and well-constructed hypothesis (reinforced throughout the various chapters) for informing methods and in guiding data interpretation. Written by prominent medical scientists and methodologists who have extensive personal experience in biomedical investigation and in teaching key aspects of research methodology to medical students, physicians and other health professionals, the authors expertly integrate theory with examples and employ language that is clear and useful for a general medical audience. A major contribution to the methodology literature, Principles of Research Methodology: A Guide for Clinical Investigators is an authoritative resource for all individuals who perform research, plan to perform it, or wish to understand it better.

Applied Epidemiologic Principles And Concepts


Author : Laurens Holmes, Jr.
language : en
Publisher: CRC Press
Release Date : 2017-12-14


PDF Download Applied Epidemiologic Principles And Concepts Books For free written by Laurens Holmes, Jr. and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-14 with Medical categories.


This book provides practical knowledge to clinicians and biomedical researchers using biological and biochemical specimen/samples in order to understand health and disease processes at cellular, clinical, and population levels. Concepts and techniques provided will help researchers design and conduct studies, then translate data from bench to clinics in attempt to improve the health of patients and populations. This book presents the extreme complexity of epidemiologic research in a concise manner that will address the issue of confounders, thus allowing for more valid inferences and yielding results that are more reliable and accurate.

Mitochondrial Replacement Techniques


Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2016-03-17


PDF Download Mitochondrial Replacement Techniques Books For free written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-17 with Medical categories.


Mitochondrial replacement techniques (MRTs) are designed to prevent the transmission of mitochondrial DNA (mtDNA) diseases from mother to child. While MRTs, if effective, could satisfy a desire of women seeking to have a genetically related child without the risk of passing on mtDNA disease, the technique raises significant ethical and social issues. It would create offspring who have genetic material from two women, something never sanctioned in humans, and would create mitochondrial changes that could be heritable (in female offspring), and therefore passed on in perpetuity. The manipulation would be performed on eggs or embryos, would affect every cell of the resulting individual, and once carried out this genetic manipulation is not reversible. Mitochondrial Replacement Techniques considers the implications of manipulating mitochondrial content both in children born to women as a result of participating in these studies and in descendants of any female offspring. This study examines the ethical and social issues related to MRTs, outlines principles that would provide a framework and foundation for oversight of MRTs, and develops recommendations to inform the Food and Drug Administration’s consideration of investigational new drug applications.

Applied Biostatistical Principles And Concepts


Author : Laurens Holmes, Jr.
language : en
Publisher: Routledge
Release Date : 2017-11-22


PDF Download Applied Biostatistical Principles And Concepts Books For free written by Laurens Holmes, Jr. and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-22 with Medical categories.


The past three decades have witnessed modern advances in statistical modeling and evidence discovery in biomedical, clinical, and population-based research. With these advances come the challenges in accurate model stipulation and application of models in scientific evidence discovery Applied Biostatistical Principles and Concepts provides practical knowledge using biological and biochemical specimen/samples in order to understand health and disease processes at cellular, clinical, and population levels. Concepts and techniques provided will help researchers design and conduct studies, then translate data from bench to clinics in attempt to improve the health of patients and populations. This book is suitable for both clinicians and health or biological sciences students. It presents the reality in statistical modelling of health research data in a concise manner that will address the issue of "big data" type I error tolerance and probability value, effect size and confidence interval for precision, effect measure modification and interaction as well as confounders, thus allowing for more valid inferences and yielding results that are more reliable, valid and accurate.

Principles And Practice Of Clinical Research


Author : John I. Gallin
language : en
Publisher: Elsevier
Release Date : 2011-04-28


PDF Download Principles And Practice Of Clinical Research Books For free written by John I. Gallin and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Medical categories.


The second edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers. *Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical Research *Addresses the vast opportunities for translation of basic science observations to the bedside through clinical research *Delves into data management and addresses how to collect data and use it for discovery *Contains valuable, up-to-date information on how to obtain funding from the federal government

Health Research Methodology


Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2001-01-01


PDF Download Health Research Methodology Books For free written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-01 with Medical categories.


To accommodate requests from readers to incorporate recent developments on research methodology and experiences of past training courses the manual has been revised and reissued. A practical training manual covering the basic concepts and principles of s

Die Street Corner Society


Author : William Foote Whyte
language : de
Publisher: Walter de Gruyter
Release Date : 1996-01-01


PDF Download Die Street Corner Society Books For free written by William Foote Whyte and has been published by Walter de Gruyter this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-01 with Social Science categories.