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Design And Analysis Of Clinical Trials


Author : Shein-Chung Chow
language : en
Publisher: John Wiley & Sons
Release Date : 2008-12-04


PDF Download Design And Analysis Of Clinical Trials Books For free written by Shein-Chung Chow and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-04 with Mathematics categories.




Quantitative Health Research Issues And Methods


Author : Curtis, Elizabeth
language : en
Publisher: McGraw-Hill Education (UK)
Release Date : 2013-09-01


PDF Download Quantitative Health Research Issues And Methods Books For free written by Curtis, Elizabeth and has been published by McGraw-Hill Education (UK) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-01 with Medical categories.


This book is a detailed and comprehensive guide to undertaking quantitative health research at postgraduate and professional level. It takes you through the entire research process, from designing the project to presenting the results and will help you execute high quality quantitative research that improves and informs clinical practice. Written by a team of research experts, this book covers common practical problems such as applying theory to research and analysing data. It also includes chapters on communicating with ethics committees, recruiting samples from vulnerable populations, audit as a research approach, quasi-experimental designs and using cognitive interviewing, making it a new and innovative offering for health researchers. Other topics covered in this book include: Ethical considerations of research Designing and planning quantitative research projects Data measurement and collection Analyzing and presenting resultsWith a strong practical focus, each chapter features examples of real-life research to illustrate the quantitative research process, as well as tips and insights into research planning and execution. This book is an essential guide for all health care professionals undertaking a postgraduate degree, as well as health researchers and practitioners who need to carry out research as part of their professional role. Contributors: Ruth Belling, Michelle Butler, Catherine Comiskey, Siobhan Corrigan, Gloria Crispino, Orla Dempsey, Suzanne Guerin, Maree Johnson, Carmel Kelly, Elaine Lehane, Maria Lohan, Susan McLaren, Deirdre Mongan, Corina Naughton, Rhona O'Connell, Elaine Pierce, Gary Rolfe, Eileen Savage, Anne Scott, Emma Stokes, Roger Watson ""Learning quantitative research is taken much for granted. This is probably why there are fewer generic books on quantitative than qualitative research. This book is long overdue. Clearly- written and well structured, it takes us through the whole journey of a research project from developing 'research questions' to 'presenting the findings', passing through philosophical underpinnings, recruitment of participants and ethical considerations. Written by an array of well-known researchers and teachers, this book will certainly appeal to new as well as seasoned researchers. Those who will use it, will not be disappointed." Kader Parahoo, University of Ulster "The title of this text is somewhat misleading. It is not only an excellent and thorough guide to qualitative health research methods; it is also an excellent introduction to all forms of qualitative research. It takes the reader gently through theoretical and ethical concerns to the practicalities and benefits of utilising qualitative approaches. As such it is that rare thing; a text that can be used by novice researchers to learn their craft, and a key reference resource for experienced research practitioners." Dr. John Cullen, School of Business, National University of Ireland, Maynooth, UK "This is a first-rate collection of essays that promotes an informed understanding of both underpinning principles and widely used techniques. A great deal of effort has clearly been invested in co-ordinating the contributions, and this has delivered clarity, complementarity and effective coverage. This is a welcome, carefully-crafted and very accessible resource that will appeal to students and researchers in healthcare and beyond." Martin Beirne, Professor of Management and Organizational Behaviour, University of Glasgow, Adam Smith Business School, UK

Methods And Applications Of Statistics In Clinical Trials Volume 1


Author : N. Balakrishnan
language : en
Publisher: John Wiley & Sons
Release Date : 2014-03-05


PDF Download Methods And Applications Of Statistics In Clinical Trials Volume 1 Books For free written by N. Balakrishnan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-05 with Medical categories.


A complete guide to the key statistical concepts essential for the design and construction of clinical trials As the newest major resource in the field of medical research, Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs presents a timely and authoritative reviewof the central statistical concepts used to build clinical trials that obtain the best results. The referenceunveils modern approaches vital to understanding, creating, and evaluating data obtained throughoutthe various stages of clinical trial design and analysis. Accessible and comprehensive, the first volume in a two-part set includes newly-written articles as well as established literature from the Wiley Encyclopedia of Clinical Trials. Illustrating a variety of statistical concepts and principles such as longitudinal data, missing data, covariates, biased-coin randomization, repeated measurements, and simple randomization, the book also provides in-depth coverage of the various trial designs found within phase I-IV trials. Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs also features: Detailed chapters on the type of trial designs, such as adaptive, crossover, group-randomized, multicenter, non-inferiority, non-randomized, open-labeled, preference, prevention, and superiority trials Over 100 contributions from leading academics, researchers, and practitioners An exploration of ongoing, cutting-edge clinical trials on early cancer and heart disease, mother-to-child human immunodeficiency virus transmission trials, and the AIDS Clinical Trials Group Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs is an excellent reference for researchers, practitioners, and students in the fields of clinicaltrials, pharmaceutics, biostatistics, medical research design, biology, biomedicine, epidemiology,and public health.

Clinical And Translational Science


Author : David Robertson
language : en
Publisher: Academic Press
Release Date : 2009-03-02


PDF Download Clinical And Translational Science Books For free written by David Robertson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-02 with Medical categories.


Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health. Clinical and Translational Science is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science. Clinical research is one of the fastest growing fields in private practice and academic medicine with practical biological, physiological, cellular, and therapeutic applications Contributions from international leaders provide insight into background and future understanding for clinical and translational science Provides the structure for complete instruction and guidance on the subject from fundamental principles, approaches and infrastructure to human genetics, human pharmacology, research in special populations, the societal context of human research, and the future of human research

A Course In Time Series Analysis


Author : Daniel Peña
language : en
Publisher: John Wiley & Sons
Release Date : 2011-01-25


PDF Download A Course In Time Series Analysis Books For free written by Daniel Peña and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-25 with Mathematics categories.


New statistical methods and future directions of research in time series A Course in Time Series Analysis demonstrates how to build time series models for univariate and multivariate time series data. It brings together material previously available only in the professional literature and presents a unified view of the most advanced procedures available for time series model building. The authors begin with basic concepts in univariate time series, providing an up-to-date presentation of ARIMA models, including the Kalman filter, outlier analysis, automatic methods for building ARIMA models, and signal extraction. They then move on to advanced topics, focusing on heteroscedastic models, nonlinear time series models, Bayesian time series analysis, nonparametric time series analysis, and neural networks. Multivariate time series coverage includes presentations on vector ARMA models, cointegration, and multivariate linear systems. Special features include: Contributions from eleven of the worldâ??s leading figures in time series Shared balance between theory and application Exercise series sets Many real data examples Consistent style and clear, common notation in all contributions 60 helpful graphs and tables Requiring no previous knowledge of the subject, A Course in Time Series Analysis is an important reference and a highly useful resource for researchers and practitioners in statistics, economics, business, engineering, and environmental analysis. An Instructor's Manual presenting detailed solutions to all the problems in he book is available upon request from the Wiley editorial department.

Statistical Modeling By Wavelets


Author : Brani Vidakovic
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-25


PDF Download Statistical Modeling By Wavelets Books For free written by Brani Vidakovic and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-25 with Mathematics categories.


A comprehensive, step-by-step introduction to wavelets in statistics. What are wavelets? What makes them increasingly indispensable in statistical nonparametrics? Why are they suitable for "time-scale" applications? How are they used to solve such problems as denoising, regression, or density estimation? Where can one find up-to-date information on these newly "discovered" mathematical objects? These are some of the questions Brani Vidakovic answers in Statistical Modeling by Wavelets. Providing a much-needed introduction to the latest tools afforded statisticians by wavelet theory, Vidakovic compiles, organizes, and explains in depth research data previously available only in disparate journal articles. He carefully balances both statistical and mathematical techniques, supplementing the material with a wealth of examples, more than 100 illustrations, and extensive references-with data sets and S-Plus wavelet overviews made available for downloading over the Internet. Both introductory and data-oriented modeling topics are featured, including: * Continuous and discrete wavelet transformations. * Statistical optimality properties of wavelet shrinkage. * Theoretical aspects of wavelet density estimation. * Bayesian modeling in the wavelet domain. * Properties of wavelet-based random functions and densities. * Several novel and important wavelet applications in statistics. * Wavelet methods in time series. Accessible to anyone with a background in advanced calculus and algebra, Statistical Modeling by Wavelets promises to become the standard reference for statisticians and engineers seeking a comprehensive introduction to an emerging field.

Combinatorial Methods In Discrete Distributions


Author : Charalambos A. Charalambides
language : en
Publisher: John Wiley & Sons
Release Date : 2005-06-24


PDF Download Combinatorial Methods In Discrete Distributions Books For free written by Charalambos A. Charalambides and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-24 with Mathematics categories.


A unique approach illustrating discrete distribution theory throughcombinatorial methods This book provides a unique approach by presenting combinatorialmethods in tandem with discrete distribution theory. This method,particular to discreteness, allows readers to gain a deeperunderstanding of theory by using applications to solve problems.The author makes extensive use of the reduction approach toconditional distributions of independent random occupancy numbers,and provides excellent studies of occupancy and sequentialoccupancy distributions, convolutions of truncated discretedistributions, and compound and mixture distributions. Combinatorial Methods in Discrete Distributions begins with abrief presentation of set theory followed by basic countingprinciples. Fundamental principles of combinatorics, finitedifferences, and discrete probability are included to give readersthe necessary foundation to the topics presented in the text. A thorough examination of the field is provided andfeatures: Stirling numbers and generalized factorial coefficients Occupancy and sequential occupancy distributions n-fold convolutions of truncated distributions Compound and mixture distributions Thoroughly worked examples aid readers in understanding complextheory and discovering how theory can be applied to solve practicalproblems. An appendix with hints and answers to the exercises helpsreaders work through the more complex sections. Reference notes areprovided at the end of each chapter, and an extensive bibliographyoffers readers a resource for additional information on specializedtopics.