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Design And Analysis Of Clinical Trials


Author : Shein-Chung Chow
language : en
Publisher: John Wiley & Sons
Release Date : 2008-12-04


PDF Download Design And Analysis Of Clinical Trials Books For free written by Shein-Chung Chow and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-04 with Mathematics categories.




Clinical And Translational Science


Author : David Robertson
language : en
Publisher: Academic Press
Release Date : 2009-03-02


PDF Download Clinical And Translational Science Books For free written by David Robertson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-02 with Medical categories.


Clinical or translational science is the field of study devoted to investigating human health and disease, interventions and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. New molecular tools and diagnostic technologies based on clinical and translational research have lead to a better understanding of human disease and the application of new therapeutics for enhanced health. Clinical and Translational Science is designed as the most authoritative and modern resource for the broad range of investigators in various medical specialties taking on the challenge of clinical research. Prepared with an international perspective, this resource begins with experimental design and investigative tools to set the scene for readers. It then moves on to human genetics and pharmacology with a focus on statistics, epidemiology, genomic information, drug discovery and development, and clinical trials. Finally, it turns to legal, social, and ethical issues of clinical research concluding with a discussion of future prospects to provide readers with a comprehensive view of the this developing area of science. Clinical research is one of the fastest growing fields in private practice and academic medicine with practical biological, physiological, cellular, and therapeutic applications Contributions from international leaders provide insight into background and future understanding for clinical and translational science Provides the structure for complete instruction and guidance on the subject from fundamental principles, approaches and infrastructure to human genetics, human pharmacology, research in special populations, the societal context of human research, and the future of human research

Foundations Of Time Series Analysis And Prediction Theory


Author : Mohsen Pourahmadi
language : en
Publisher: John Wiley & Sons
Release Date : 2001-06


PDF Download Foundations Of Time Series Analysis And Prediction Theory Books For free written by Mohsen Pourahmadi and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-06 with Mathematics categories.


The author emphasizes the foundation and structure of time series and backs up this coverage with theory and application.".

A Course In Time Series Analysis


Author : Daniel Peña
language : en
Publisher: John Wiley & Sons
Release Date : 2011-01-25


PDF Download A Course In Time Series Analysis Books For free written by Daniel Peña and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-25 with Mathematics categories.


New statistical methods and future directions of research in time series A Course in Time Series Analysis demonstrates how to build time series models for univariate and multivariate time series data. It brings together material previously available only in the professional literature and presents a unified view of the most advanced procedures available for time series model building. The authors begin with basic concepts in univariate time series, providing an up-to-date presentation of ARIMA models, including the Kalman filter, outlier analysis, automatic methods for building ARIMA models, and signal extraction. They then move on to advanced topics, focusing on heteroscedastic models, nonlinear time series models, Bayesian time series analysis, nonparametric time series analysis, and neural networks. Multivariate time series coverage includes presentations on vector ARMA models, cointegration, and multivariate linear systems. Special features include: Contributions from eleven of the worldâ??s leading figures in time series Shared balance between theory and application Exercise series sets Many real data examples Consistent style and clear, common notation in all contributions 60 helpful graphs and tables Requiring no previous knowledge of the subject, A Course in Time Series Analysis is an important reference and a highly useful resource for researchers and practitioners in statistics, economics, business, engineering, and environmental analysis. An Instructor's Manual presenting detailed solutions to all the problems in he book is available upon request from the Wiley editorial department.

Clinical Trial Design


Author : Guosheng Yin
language : en
Publisher: John Wiley & Sons
Release Date : 2012-01-03


PDF Download Clinical Trial Design Books For free written by Guosheng Yin and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-03 with Mathematics categories.


There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. nevertheless, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. This book provides an overview of the fundamentals of clinical trials, the key terminologies and concepts, and a brief review and comparison on Bayesian and frequentist estimation and inference procedures. From the practical point of view, this book introduces various statistical methods that are commonly used for designing clinical trials and interim monitoring and analysis. Adaptation has a broad meaning in both Bayesian and frequentist perspectives, such as dose finding, trial early stopping for futility or superiority, dropping or adding an arm, seamless transitions between consecutive phases, group sequential methods, sample size re-estimation, adaptive randomization, and subpopulation enrichment, etc. Comprehensive discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials are provided, as well as an introduction on phase IV trials. Many practical issues and challenges arising in clinical trials are addressed, and while the book mainly focuses on the Bayesian approaches for phase I and II trial designs, many important frequentist methods for phase III clinical trails are included. In addition, advanced and up-to-date topics such as jointly modeling toxicity and efficacy, seamless phase I/II trial designs, multiple testing, causal inference and noncompliance, adaptive randomization, issues associated with delayed outcomes, dose finding with combined drugs, and targeted therapy designs in personalized medicine development are discussed. Chapter coverage includes Fundamentals of Clinical Trials; Frequentist versus Bayesian Statistics; Phase I, II, and III Trial Designs, Adaptive Randomization, Late-onset Toxicity, Drug-combination Trials, and Targeted Therapy Design.

Models For Investors In Real World Markets


Author : James R. Thompson
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-25


PDF Download Models For Investors In Real World Markets Books For free written by James R. Thompson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-25 with Mathematics categories.


* Considers neoclassical models in light of results that can go wrong with them to bring about better models. * Questions the assumption that markets clear quickly. * Offers a timely examination of the LTCM collapse. * Written by a group of well-respected and highly qualified authors.

Statistical Modeling By Wavelets


Author : Brani Vidakovic
language : en
Publisher: John Wiley & Sons
Release Date : 2009-09-25


PDF Download Statistical Modeling By Wavelets Books For free written by Brani Vidakovic and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-25 with Mathematics categories.


A comprehensive, step-by-step introduction to wavelets in statistics. What are wavelets? What makes them increasingly indispensable in statistical nonparametrics? Why are they suitable for "time-scale" applications? How are they used to solve such problems as denoising, regression, or density estimation? Where can one find up-to-date information on these newly "discovered" mathematical objects? These are some of the questions Brani Vidakovic answers in Statistical Modeling by Wavelets. Providing a much-needed introduction to the latest tools afforded statisticians by wavelet theory, Vidakovic compiles, organizes, and explains in depth research data previously available only in disparate journal articles. He carefully balances both statistical and mathematical techniques, supplementing the material with a wealth of examples, more than 100 illustrations, and extensive references-with data sets and S-Plus wavelet overviews made available for downloading over the Internet. Both introductory and data-oriented modeling topics are featured, including: * Continuous and discrete wavelet transformations. * Statistical optimality properties of wavelet shrinkage. * Theoretical aspects of wavelet density estimation. * Bayesian modeling in the wavelet domain. * Properties of wavelet-based random functions and densities. * Several novel and important wavelet applications in statistics. * Wavelet methods in time series. Accessible to anyone with a background in advanced calculus and algebra, Statistical Modeling by Wavelets promises to become the standard reference for statisticians and engineers seeking a comprehensive introduction to an emerging field.